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Outcome of interest
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Univariable Analysis
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Multivariable analysis
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OR
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95% CI
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p value
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OR
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95% CI
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p value
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Mace
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CVD History
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2.06
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1.69 – 2.50
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< 0.001
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1.32
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1.05 – 1.67
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0.018
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Cancer Historya
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1.63
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1.26 – 2.11
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< 0.001
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Among Males
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0.85
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0.65 – 1.12
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0.26
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Among Females
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1.59
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1.02 – 2.48
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0.039
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Severe Disease Complication
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CVD History
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1.26
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1.12 – 1.41
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< 0.0001
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0.91
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0.78 – 1.07
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0.26
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Cancer Historyb
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1.15
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0.99 – 1.34
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0.062
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Among Smokersc
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2.76
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1.98 – 3.86
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< 0.001
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Among Non-Smokerc
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1.12
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0.91 – 1.37
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0.29
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Thromboembolic Event
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CVD History
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1.01
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0.73 – 1.38
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0.97
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0.93
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0.68 – 1.28
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0.653
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Cancer History
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1.21
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0.82 – 1.80
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0.34
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0.86
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0.55 – 1.32
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0.482
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- All multivariable models were adjusted for age, gender, body mass index, race, diabetes, hypertension, hyperlipidemia, smoking history, chronic kidney disease, and pulmonary disease
- CVD Cardiovascular Disease
- aThe following interaction term is found to be significant in the multivariable logistic regression analysis for the outcome of MACE and retained in the final model: Gender*Cancer History (p = 0.03)
- b The following interaction terms are found to be significant in the multivariable logistic regression analysis for the outcome of severe disease complications and retained in the final model: Age*Cancer History (p = 0.01) and Smoking History*Cancer History (p = 0.003)
- c Evaluated at an average age (61.5 years) in the study cohort
