Fig. 1
From: CBR3 V244M is associated with LVEF reduction in breast cancer patients treated with doxorubicin
Left ventricular systolic function in adult breast cancer patients treated with DOX by echocardiogram at baseline and 6 months. We obtained apical two-chamber and four-chamber echocardiographic images at baseline (prior to DOX treatment; t0m) and 6 months (±2 weeks) following the initiation of DOX therapy (t6m). These images were used to calculate LVEF using Simpson’s biplane rule by investigators blinded to all patient data. The data was graphed as a violin plot showing the median (thick dashed line), quartiles (dotted line) and overall distribution of LVEF by CBR3 V244M genotype (AA, AG, GG) at t0m and t6m. p < 0.0001, two-way ANOVA