Risk of malignancy long after acute coronary syndrome in selected urban and rural areas and comparison with smoking risk: the ABC-7* study on Heart Disease

Table 2 Logistic regression analysis of overall malignancy risk and COX regression analysis of the risk of neoplasia onset over 22 years of follow-up after ACS with the interaction for risks between six geographic areas and by smoking habit

	Unadjusted model			Fully adjusted model
Logistic regression analysis (n = 586)	OR (95 % CI)		P -value	OR (95 % CI)		P -value
Urban-rural areas	3.4 (1.7–7.1)		0.001	3.4 (1.6–7.3)		0.001*
North-south provinces	1.5 (1.0-2.2)		0.06	1.4 (0.9–2.1)		0.11*
Interaction (urban/rural areas and south to north provinces)	2.1 (1.2–3.6)		0.003	2.1 (1.2–3.6)		0.003*
Smoking habit	2.5 (1.6–4.1)		< 0.0001	2.4 (1.3–4.6)		0.006†
Cox regression analysis (n = 526)	HR (95 % CI)	Z	P -value	HR (95 % CI)	Z	P -value
Urban-rural areas	3.0 (1.5–6.2)	3.1	0.002	3.2 (1.6–6.6)	3.2	0.001*
North-south provinces	1.3 (1.0–2.0)	1.5	0.14	1.4 (1.0-2.1)	1.8	0.08*
Interaction (urban/rural areas and south to north provinces)	2.1 (1.3–3.5)	3.1	0.002	2.2 (1.4–3.6)	3.2	0.001*
Smoking habit	1.8 (0.8-4.0)	1.5	0.13	2.9 (1.2–7.21)	2.4	0.01†

OR odds ratio; CI confidence interval; HR hazard ratio
*Adjusted for age, gender, smoking, alcohol consumption, education level, baseline serum cholesterol, and presence of heart failure at admission
† Adjusted for age, gender, province, alcohol consumption, education level, baseline serum cholesterol, and presence of heart failure at admission

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