You are viewing the site in preview mode

Skip to main content

Table 1 List of Selected Studies with Their Demographics, Duration, Sample Size, Mean Age, Radiation Doses, and Cardiovascular Outcomes

From: Gender disparity in cardiovascular mortality following radiation therapy for Hodgkin’s lymphoma: a systematic review

Trial Information Country Duration Sample (%) Mean Age (Years) Median Radiation Dose (Gy) Outcome
Female Male
Boivin 1982, [19]
Retrospective study
USA 33.0 years 44.2 55.8 < 44 > 30 CV mortality
Galper 2011, [2]
Retrospective study
USA 14.7 years 53.6 46.4 47 > 36 CAD (MI, CABG, PTCA), arrhythmias (AICD), valvular disease, pericardial disease
Giancolo 2010, [20]
Prospective study
Italy 5.0 months 46.4 53.6 47.8 +/− 17.4 41.2+/−15.6 CIMT
Hahn 2017, [21]
Retrospective study
Canada One time analysis 39.2 60.8 34.2 25 Ischemic CVD
Heidenreich 2007, [22]
Prospective study
USA One time analysis 45.4 54.6 42 > 35 Asymptomatic CAD stress testing, followed by coronary angiography if positive stress test
Hoppe 1997, [23]
Prospective study
USA 35.0 years 41.0 59.0 NA > 30 Cardiac heart disease (pericarditis, coronary artery disease, functional valvular/conduction defects)
Hull 2003, [10]
Retrospective study
USA 11.2 years 39.0 61.0 25 33 CAD (MI, CABG, PCI, > 75% stenosis)
Schellong 2010, [24]
Prospective study
Germany, Austria 29.4 years 41.7 58.3 27.9 > 30 Cardiac heart disease (pericarditis, coronary artery disease, functional valvular/conduction defects)
Swerdlow 2007, [25]
Prospective study
UK 25.0 years 38.1 61.9 34 > 30 CVD mortality
Tsai 2011, [26]
Prospective study
Norway 20.0–24.0 years 77.5 22.5 51 +/− 9 41 LV wall motion and EF, and CAD
  1. Abbreviations: UK United Kingdom, CVD Cardiovascular Disease, CAD Coronary Artery Disease, MI Myocardial Infarction, CABG Coronary Artery Bypass Graft, PTCA Percutaneous Coronary Balloon Angiogram, AICD Automatic Intrac-cardiac Defibrillator, CIMT Common Carotid Intima-Media Thickness, PCI Percutaneous Coronary Intervention, LV Left Ventricle, EF Ejection Fraction